After Homer accidentally pollutes the town's water supply, Springfield is encased in a gigantic dome by the EPA and the Simpsons are declared fugitives.
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Dan Castellaneta as Homer / Itchy / Barney / Grampa / Stage Manager / Krusty the Clown / Mayor Quimby / Mayor's Aide / Multi-Eyed Squirrel / Panicky Man / Sideshow Mel / Mr. Teeny / EPA Official / Kissing Cop / Bear / Boy on Phone / NSA Worker / Officer / Santa's Little Helper / Squeaky-Voiced Teen (voice) |
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Julie Kavner as Marge Simpson / Selma / Patty (voice) |
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Nancy Cartwright as Bart Simpson / Maggie Simpson / Ralph / Nelson / Todd Flanders / TV Daughter / Woman on Phone (voice) |
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Yeardley Smith as Lisa Simpson (voice) |
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Hank Azaria as Professor Frink / Comic Book Guy / Moe / Chief Wiggum / Lou / Carl / Cletus / Bumblebee Man / Male EPA Worker / Dome Depot Announcer / Kissing Cop / Carnival Barker / Counter Man / Apu / Drederick Tatum / Sea Captain / EPA Passenger / Robot / Dr. Nick / Wise Guy (voice) |
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Harry Shearer as Scratchy / Mr. Burns / Rev. Lovejoy / Ned Flanders / Lenny / Skull / President Arnold Schwarzenegger / Kent Brockman / Principal Skinner / Dr. Hibbert / Smithers / Toll Booth Man / Guard / Otto / Kang (voice) |
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Kelsey Grammer as Sideshow Bob (voice) |
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Pamela Hayden as Milhouse Van Houten / Jimbo Jones / Rod Flanders (voice) |
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Marcia Wallace as Mrs. Krabappel (voice) |
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Joe Mantegna as Fat Tony (voice) |
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Tom Hanks as Himself (voice) |
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Billie Joe Armstrong as Green Day (voice) |
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Mike Dirnt as Green Day (voice) |
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Tre Cool as Green Day (voice) |
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Tress MacNeille as Sweet Old Lady / Colin / Mrs. Skinner / Nelson's Mother / Pig / Cat Lady / Female EPA Worker / G.P.S. Woman / Cookie Kwan / Lindsey Naegle / TV Son / Medicine Woman / Girl on Phone (voice) |
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Albert Brooks as Russ Cargill (voice) |
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Russi Taylor as Martin (voice) |
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Karl Wiedergott as Man / EPA Driver (voice) |
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Maggie Roswell as Helen Lovejoy (voice) |
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Philip Rosenthal as TV Dad (voice) |
| Directing | David Silverman | Director |
| Writing | Matt Groening | Screenplay |
| Writing | James L. Brooks | Screenplay |
| Writing | Sam Simon | Screenplay |
| Writing | Al Jean | Screenplay |
| Writing | Ian Maxtone-Graham | Screenplay |
| Writing | George Meyer | Screenplay |
| Writing | David Mirkin | Screenplay |
| Writing | Mike Reiss | Screenplay |
| Writing | Mike Scully | Screenplay |
| Writing | Matt Selman | Screenplay |
| Writing | John Swartzwelder | Screenplay |
| Writing | Jon Vitti | Screenplay |
| Production | James L. Brooks | Producer |
| Production | Matt Groening | Producer |
| Production | Al Jean | Producer |
| Production | Richard Sakai | Producer |
| Production | Mike Scully | Producer |
| Production | Jay Kleckner | Producer |
| Production | Peter Gave | Producer |
| Production | Amanda Moshay | Producer |
| Production | Felicia Nalivansky | Producer |
| Production | Matt Orefice | Producer |
| Production | Nikki Vanzo | Executive Producer |
| Sound | Hans Zimmer | Original Music Composer |
| Editing | John Carnochan | Editor |
| Art | Dima Malanitchev | Art Direction |
| Production | Claudia Katz | Producer |
| Directing | Jay Jackson | Layout |
| Directing | Matthew Schofield | Assistant Director |
| Visual Effects | Anthony DeRosa | Animation |
| Visual Effects | John Pomeroy | Animation |
| Crew | Miae Kim | Compositors |
| Crew | Colin Sittig | Compositors |
| Crew | Beth S. Morris | Compositors |
| Crew | Darrin Drew | Compositors |
| Directing | Frans Vischer | Layout |
| Production | Craig Sost | Co-Producer |
| Visual Effects | Sun Jae Lee | Animation |
| Crew | Louie C. Jhocson | Compositors |
| Crew | Rick Moser | Compositors |
| Crew | Edwin Shortess | Compositors |
| Crew | Jeannine Berger | Post Production Supervisor |
| Directing | Richard Manginsay | Layout |
| Directing | Eric Koenig | Layout |
| Directing | Eddie Rosas | Layout |
| Directing | Manny DeGuzman | Layout |
| Crew | Brendan Harris | Compositors |
| Directing | Nate Lowe | Layout |
| Visual Effects | Gary McCarver | Animation Director |
| Visual Effects | Caroline Cruikshank | Animation |
| Visual Effects | Silvia Pompei | Animation |
| Crew | Dennis Bonnell | Compositors |
| Directing | Juan 'Jo' Luna | Layout |
| Crew | Bingo Ferguson | Compositors |
| Directing | J.C. Wegman | Layout |
| Directing | Jeff Johnson | Layout |
| Crew | Doug Tiano | Compositors |
| Directing | Rufino Camacho | Layout |
| Directing | Ivaylo Anguelov | Layout |
| Directing | Jennifer Moeller | Layout |
| Directing | Andre Medina | Layout |
| Directing | Roberto Casale | Layout |
| Sound | Gwendolyn Yates Whittle | Supervising Sound Editor |
| Sound | Daniel Pinder | Supervising Music Editor |
| Editing | Roger Injarusorn | Editorial Services |
